SELF-PACED LEARNING and
TERATOLOGY – DYSMORPHOLOGY
Signs and Signals
TO TERATOLOGY - DYSMORPHOLOGY
NOTE: Emphases are on signs and signals and NOT on etiology, pathogenesis,
diagnosis, therapies and prevention.
DYSMORPHOLOGY, GENETICS – IN ESSENCE
PRINCIPLES OF TERATOLOGY
RENAISSANCE OF MEDICAL TERATOLOGY – MASTER
COMMENT: Dr. Josef Warkany is
arguably the main pioneer of modern scientific Teratology and
the creation of the International, Japanese, and European Teratology Societies.
He also indisputably is credited with the demonstration that the embryo-fetus
can be damaged by environmental factors now referred to as teratogens.
Warkany’s investigations provided a basis to adoption of laws requiring
that pharmaceuticals be tested regarding their teratogenic potential.
Warkany’s achievements also led to the demise of Eugenics which
provided a basis for laws justifying euthanasia.
Warkany’s Gestation of the
Perspective by invitation of
the Teratology Society
On Dreaming on Solid Grounds
LAWS of HUMAN CLINICAL TERATOLOGY
English, Ukrainian, 13 min.)
SIGNS – SIGNALS … SEMIOLOGY
(English, 17 min.; Ukrainian, 17 min.)
(English, 47 min.)
BLASTOPATHIES – TWINNING
TERATOGENS – MEDICATIONS and …
UTIS – Ukrainian Teratology Information System (in
Ukrainian) OTIS – Mother to Baby - Organization of Teratology
DOWN SYNDROME VIRTUAL CLINIC
DYSMORPHOLOGY SYNTHESIS and
PROCESS from SIGN/SIGNAL/ETIOLOGY
to SYNDROMES/DIAGNOSIS/PROGNOSIS …
– EXTREME CLINICAL VARIABILITY
Some dysmorphic anomalies and syndromes due to the same etiology can manifest
in minimal or quiet severe signs. This point cannot be overemphasized. An image
is worth a thousand words.
Fetal Alcohol Spectrum Disorder (FASD)
Typical FASD facies
COMMENT: Alcohol teratogenesis and FAS-FASD syndromes are a prototype of
specific teratogenic effects due to a specific teratogen. Therefore, because of
the high frequency of alcohol consumption (including by women who accidentally
become pregnant, the subject is explored extensively. All clinicians have a
role in preventing FAS-FASD. Please explore a variety of master-classes, videos
and image galleries. Please use the link below.
ENDOGENOUS TERATOGENS – SINGLE GENE MUTATION
COMMENT: Endogenous teratogens, for the most part are reflections of gene
mutations, chromosomal imbalances, or “physical - mechanical” in utero events
“accidents”, such as vascular ruptures, premature or delayed death of cells
(apoptosis), etc. The prototype alluded to below is a syndrome that all
physician, regardless of their specialties, must be able to recognize or at
least suspect this syndrome. Early diagnosis can be lifesaving.
The importance of this category of disorders prompts us to show below links
to clinical outlines.